Basic Information
| LncRNA/CircRNA Name | circSERPINA3 |
| Synonyms | circ_0033074 |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qPCR, Western blotting |
| Sample | nasopharyngeal cancer tissues and cell lines |
| Expression Pattern | up-regulated |
| Function Description | In this study, it was demonstrated that that hsa_circ_0033074 (circSERPINA3) expression was found to be significantly upregulated in NPC tissues and cell lines. CircSERPINA3 inhibition significantly attenuated the invasion and proliferation abilities of NPC cells. The mechanism by which circSERPINA3 interacted with miR-944 was identified and MDM2 was demonstrated to function as a target gene of miR-944. |
| Pubmed ID | 32328195 |
| Year | 2020 |
| Title | Cell proliferation and invasion is promoted by circSERPINA3 in nasopharyngeal carcinoma by regulating miR-944/MDM2 axis |
External Links
| Links for circSERPINA3 | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |