Basic Information
| LncRNA/CircRNA Name | circHMCU |
| Synonyms | |
| Region | |
| Ensemble | |
| Refseq |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blotting |
| Sample | breast cancer tissues and cell lines |
| Expression Pattern | up-regulated |
| Function Description | In the present study we found a circRNA termed circHMCU whose expression was associated with poor prognosis. n vitro results proved that circHMCU could significantly promote proliferation, migration, and invasion abilities of breast cancer cells via affecting the G1 phase cell cycle checkpoint and the epithelial-mesenchymal transition (EMT) pathway. Further in vivo studies showed that overexpression of circHMCU contributed to rapid proliferation and lung metastasis of breast cancer. |
| Pubmed ID | 32330870 |
| Year | 2020 |
| Title | circHMCU Promotes Proliferation and Metastasis of Breast Cancer by Sponging the let-7 Family |
External Links
| Links for circHMCU | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |