Basic Information
LncRNA/CircRNA Name | CASC9 |
Synonyms | Cancer susceptibility candidate 9 |
Region | GRCh38_8:75223404-75324741 |
Ensemble | ENSG00000249395 |
Refseq | NR_103848 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | apoptosis | Drug | ||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | laryngeal cancer |
ICD-0-3 | C32 |
Methods | qRT-PCR |
Sample | LC tumor tissues,oral keratinocytes (HOK) cells and human laryngeal squamous cell carcinoma TU212 and Hep-2 cells |
Expression Pattern | up-regulated |
Function Description | higher expression of CASC9 and GLUT-1 in laryngeal carcinoma tissues and cells, compared to adjacent tissues and cells.overexpressing CASC9 increased and silencing CASC9 decreased cell migration of TU212 and Hep-2 cells. A flow cytometry assay showed that overexpressing CASC9 reduced and silencing CASC9 increased cell apoptosis.overexpressing CASC9 increased cell proliferation and cell migration and decreased apoptosis both in TU212 and Hep-2 cells, whereas silencing CASC9 had the opposite effects. |
Pubmed ID | 31669650 |
Year | 2020 |
Title | GLUT-1 Participates in the Promotion of LncRNA CASC9 in Proliferation and Metastasis of Laryngeal Carcinoma Cells |
External Links
Links for CASC9 | GenBank HGNC NONCODE |
Links for laryngeal cancer | OMIM COSMIC |