Basic Information
| LncRNA/CircRNA Name | CASC9 |
| Synonyms | cancer susceptibility 9 |
| Region | GRCh38_8:75223404-75324741 |
| Ensemble | ENSG00000249395 |
| Refseq | NR_103848 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | Western blot, RT-PCR, RIP |
| Sample | Lung cancer specimens,lung epithelial cell line HFL-1, and lung cancer cell lines 95D, A549, PC-9, SPC-A1 and HAC-84 |
| Expression Pattern | up-regulated |
| Function Description | CASC9 was overexpressed in lung cancer specimens and cell lines. Knockdown of CASC9 inhibited cell proliferation, migration, invasion and EMT in lung cancer cells. While overexpression of CASC9 in normal lung epithelial cells did the opposite. CASC9 interacted with HIF-1? and enhanced its protein stability. |
| Pubmed ID | 31802910 |
| Year | 2019 |
| Title | Long Non-Coding RNA CASC9 And HIF-1? Form A Positive Feedback Loop To Facilitate Cell Proliferation And Metastasis In Lung Cancer |
External Links
| Links for CASC9 | GenBank HGNC NONCODE |
| Links for lung cancer | OMIM COSMIC |