Basic Information
| LncRNA/CircRNA Name | TINCR |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | squamous cell cancer |
| ICD-0-3 | C44 |
| Methods | qPCR, RNAi, Western blot, Cell proliferation assay etc. |
| Sample | cell line (SCC13) |
| Expression Pattern | differential expression |
| Function Description | Upregulation of TINCR transcripts in ZNF750 over-expressing SCC cells , and the downregulation of TINCR in ZNF750 depleted cells. Moreover, transcripts of both TNCR and ZNF750 are activated during epidermal lineage induction. Depletion of TINCR by siRNA resulted in an increased cell growth as well as migration activity. In addition, Kaplan??eier analysis revealed that low levels of TINCR were significantly correlated with poor outcome of patients with HNSCC in the TCGA cohort. |
| Pubmed ID | 27819679 |
| Year | 2016 |
| Title | ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma. |
External Links
| Links for TINCR | GenBank HGNC NONCODE |
| Links for squamous cell cancer | OMIM COSMIC |