Basic Information
| LncRNA/CircRNA Name | ZNF674-AS1 |
| Synonyms | ZNF674-AS1 |
| Region | GRCh38_X:46545493-46548408 |
| Ensemble | ENSG00000230844 |
| Refseq | NR_015378 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR etc. |
| Sample | HCC tissues, cell lines (HepG2, HCCLM3, SK-Hep1, HuH7, Hep3B, and MHCC97H) |
| Expression Pattern | down-regulated |
| Function Description | The expression of ZNF674-AS1 in the HCC cell lines was significantly downregulated compared with that in the normal liver cell line. The expression of ZNF674-AS1 was downregulated in 72% (99/137) of HCC tissues compared with that in paired adjacent normal tissues. The results showed that the ZNF674-AS1 expression level was significantly correlated with metastasis, clinical stage, and histopathologic grading. |
| Pubmed ID | 27896271 |
| Year | 2016 |
| Title | Expression and Clinical Significance of the Novel Long Noncoding RNA ZNF674-AS1 in Human Hepatocellular Carcinoma. |
External Links
| Links for ZNF674-AS1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |