Basic Information
| LncRNA/CircRNA Name | CASC9 |
| Synonyms | cancer susceptibility candidate 9 |
| Region | GRCh38_8:75223404-75324741 |
| Ensemble | ENSG00000249395 |
| Refseq | NR_103848 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qRT-PCR, Western blot, Luciferase activity assay, RIP |
| Sample | NPC tissues,nasopharyngeal cell line NP69 and the NPC cell lines HNE1, SUNE1, CNE1, and HONE1 |
| Expression Pattern | up-regulated |
| Function Description | The expression level of CASC9 was upregulated in NPC tissues and cells. The knockdown of CASC9 evidently suppressed migration and invasion but promoted apoptosis in NPC cells. In addition, the inhibition of CASC9 evidently increased the BAX protein level and inhibited the expression of the Bcl-2, MMP 9, and MPP2 proteins in NPC cells. the knockdown of CASC9 inhibited tumor growth in vivo. |
| Pubmed ID | 31933798 |
| Year | 2019 |
| Title | Long Non-Coding RNA CASC9 Knockdown Inhibits the Progression of Nasopharyngeal Carcinoma by Regulating miR-145 |
External Links
| Links for CASC9 | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |