Basic Information
| LncRNA/CircRNA Name | ZNF667-AS1 |
| Synonyms | NA |
| Region | GRCh38_19:56477250-56500666 |
| Ensemble | ENSG00000166770 |
| Refseq | NR_036521 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Luciferase reporter constructs and Dual luciferase reporter assay, Western blot analysis, RIP |
| Sample | Primary ESCC tissues,esophageal cancer cell lines (Kyse170, Eca109, TE1, and TE13) |
| Expression Pattern | down-regulated |
| Function Description | Frequent downregulation of ZNF667-AS1 and ZNF667 was detected in esophageal cancer cells and ESCC tissues.Overexpression of ZNF667-AS1 and ZNF667 suppressed the viability, migration, and invasion of esophageal cancer cells in vitro. Overexpression of ZNF667-AS1 increased mRNA and protein expression level of ZNF667. ZNF667-AS1 interacts with and recruits TET1 to its target gene ZNF667 and E-cadherin to hydrolyze 5'-mc to 5'-hmc and further activates their expression, meanwhile, ZNF667-AS1 also interacts with UTX to decrease histone H3K27 tri-methylation to activate ZNF667 and E-cadherin expression. |
| Pubmed ID | 31804468 |
| Year | 2019 |
| Title | Aberrant Hypermethylation-Mediated Downregulation of Antisense lncRNA ZNF667-AS1 and Its Sense Gene ZNF667 Correlate With Progression and Prognosis of Esophageal Squamous Cell Carcinoma |
External Links
| Links for ZNF667-AS1 | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |