Basic Information
| LncRNA/CircRNA Name | ZFPM2-AS1 |
| Synonyms | ZFPM2 antisense RNA 1 |
| Region | GRCh38_8:105780246-106060524 |
| Ensemble | ENSG00000251003 |
| Refseq | NR_125796 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qRT-PCR, Western blot analysis, Luciferase reporter assay, RIP |
| Sample | nontumor cell line BEAS-2B and four human LUAD cell lines (H1299, H1975, A549, and H2228) |
| Expression Pattern | up-regulated |
| Function Description | an upregulation of ZFPM2-AS1 in LUAD cell lines.ZFPM2-AS1 depletion impaired cell viability, suppressed cell migration, and reversed epithelial-mesenchymal transition progress in LUAD cells.ZFPM2-AS1 was distributed in the cytoplasm of LUAD cells.ZFPM2-AS1 functioned as a molecular sponge of miR-511-3p, which was a suppressor in LUAD. |
| Pubmed ID | 31692047 |
| Year | 2020 |
| Title | Long Noncoding RNA ZFPM2-AS1 Is Involved in Lung Adenocarcinoma via miR-511-3p/AFF4 Pathway |
External Links
| Links for ZFPM2-AS1 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |