Basic Information
| LncRNA/CircRNA Name | ZFPM2-AS1 |
| Synonyms | Zinc finger protein multitype 2 antisense RNA 1 |
| Region | GRCh38_8:105780246-106060524 |
| Ensemble | ENSG00000251003 |
| Refseq | NR_125796 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qRT-PCR, Luciferase reporter assay, RIP, Western blot |
| Sample | human LUAD cell lines (SPC-A1, A549, H1299, and PC9) and the normal human bronchial epithelial cell line |
| Expression Pattern | up-regulated |
| Function Description | ZFPM2-AS1 expression is high in LUAD samples.ZFPM2-AS1 facilitated proliferation, invasion, and epithelial-to-mesenchymal transition of LUAD cells. Thereafter, we found that ZFPM2 was negatively regulated by ZFPM2-AS1, and identified the suppressive effect of ZFPM2 regulation by ZFPM2-AS1 on LUAD progression. Mechanistically, we showed that ZFPM2-AS1 interacted with up-frameshift 1 (UPF1) to regulate mRNA decay of ZFPM2. |
| Pubmed ID | 31919993 |
| Year | 2020 |
| Title | LncRNA ZFPM2-AS1 Promotes Lung Adenocarcinoma Progression by Interacting With UPF1 to Destabilize ZFPM2 |
External Links
| Links for ZFPM2-AS1 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |