Basic Information
LncRNA/CircRNA Name | ZFAS1 |
Synonyms | ZFAS1, C20orf199, HSUP1, HSUP2, NCRNA00275, ZNFX1-AS1 |
Region | GRCh38_20:49278178-49295738 |
Ensemble | ENSG00000177410 |
Refseq | NR_003604 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | gastric cancer |
ICD-0-3 | C16 |
Methods | qPCR, Western blot, in vitro knockdown etc. |
Sample | cell line(SGC7901), gastric cancer tissues |
Expression Pattern | up-regulated |
Function Description | The silencing of ZFAS1 inhibited the growth, proliferation, cell cycle progress, migration, invasion and epithelial-mesenchymal transition (EMT), and enhanced the sensitivity to cis-platinum or paclitaxel in SGC7901 cells, as evidenced by the expression changes of proliferating cell nuclear antigen, Cyclin D1, Cyclin E, Cyclin B1, E-cadherin, N-cadherin, vimentin, matrix metalloproteinase (MMP)-2 and MMP-14. The ZFAS1 also activated the Wnt/B-catenin signaling. |
Pubmed ID | 29424266 |
Year | 2018 |
Title | Silencing of lncRNA ZFAS1 inhibits malignancies by blocking Wnt/B-catenin signaling in gastric cancer cells. |
External Links
Links for ZFAS1 | GenBank HGNC NONCODE |
Links for gastric cancer | OMIM COSMIC |