Basic Information
| LncRNA/CircRNA Name | ZFAS1 |
| Synonyms | ZFAS1, C20orf199, HSUP1, HSUP2, NCRNA00275, ZNFX1-AS1 |
| Region | GRCh38_20:49278178-49295738 |
| Ensemble | ENSG00000177410 |
| Refseq | NR_003604 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RNAi, Cell migration and invasion assay etc. |
| Sample | CRC tissues, cell lines (HCT8, HCT116, HT29, LoVo, SW480, SW620 and HEK-293T) |
| Expression Pattern | up-regulated |
| Function Description | The ZFAS1 expression was significantly upregulated in 47.8% (76 of 159) of cancerous tissues compared with NCTs, and was higher in metastatic tumors than in corresponding primary CRC tumors. ZFAS1 expression in CRC was positively correlated with lymphatic invasion and TNM stage. Patients with increased ZFAS1 expression showed shorter relapse-free survival and overall survival. The knockdown of ZFAS1 decreased cell migration and invasive ability of LoVo and HCT116 cells in vitro. Moreover, silencing ZFAS1 expression inhibited the in vivo metastasis of CRC cells. |
| Pubmed ID | 27461828 |
| Year | 2016 |
| Title | Upregulation of long noncoding RNA ZFAS1 predicts poor prognosis and prompts invasion and metastasis in colorectal cancer. |
External Links
| Links for ZFAS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |