Basic Information
| LncRNA/CircRNA Name | ZFAS1 |
| Synonyms | ZFAS1, C20orf199, HSUP1, HSUP2, NCRNA00275, ZNFX1-AS1 |
| Region | GRCh38_20:49278178-49295738 |
| Ensemble | ENSG00000177410 |
| Refseq | NR_003604 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Luciferase reporter assay |
| Sample | colorectal cancer tissues, cell lines (HCT116, SW480, SW620, HT-29 and LOVO, HCoEpiC) |
| Expression Pattern | up-regulated |
| Function Description | ZFAS1 expression was significantly upregulated in CRC tissues and cell lines. high ZFAS1 expression was significantly associated with Helicobacter pylori infection, lymph nodes metastasis, advanced TNM stage and poor overall survival of CRC patients. ZFAS1 inhibition could markedly suppress CRC cells proliferation and invasion both in vitro and in vivo.ZFAS1 directly interacted with miR-484. miR-484 inhibitor reversed the tumor suppressing roles of ZFAS1 knockdown on CRC cells. |
| Pubmed ID | 29179614 |
| Year | 2017 |
| Title | Long non-coding RNA ZFAS1 sponges miR-484 to promote cell proliferation and invasion in colorectal cancer. |
External Links
| Links for ZFAS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |