Basic Information
| LncRNA/CircRNA Name | ZFAS1 |
| Synonyms | ZFAS1, C20orf199, HSUP1, HSUP2, NCRNA00275, ZNFX1-AS1 |
| Region | GRCh38_20:49278178-49295738 |
| Ensemble | ENSG00000177410 |
| Refseq | NR_003604 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, Western blot, Flow cytometry assay, Cell proliferation assay etc. |
| Sample | colon cancer tissues, cell lines (SW480, CaCO-2, RKO, HCT8, HCT116, and SW620) |
| Expression Pattern | up-regulated |
| Function Description | ZFAS1 was up-regulated in colonic cancer tissues compared with adjacent mucosa, and its expression level was significantly correlated with TNM stage, vascular invasion and lymph node metastasis. ZFAS1 and ZEB1 were also increased in patients' plasma. Moreover, ZFAS1 promoted proliferation, invasion and impeded apoptosis. Knockdown of ZFAS1 decreased expression of ZEB1 and increased the epithelial markers E-cadherin, ZO-1 while decreasing mesenchymal markers vimentin and N-cadherin. |
| Pubmed ID | 27862275 |
| Year | 2016 |
| Title | Long Noncoding RNA ZFAS1 promotes the progression of colonic cancer by modulating ZEB1 expression. |
External Links
| Links for ZFAS1 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |