Basic Information
| LncRNA/CircRNA Name | ZFAS1 |
| Synonyms | NA |
| Region | GRCh38_20:49278178-49295738 |
| Ensemble | ENSG00000177410 |
| Refseq | NR_003604 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qPCR, Luciferase reporter assay, in vitro knockdown, RIP |
| Sample | The human nasopharyngeal epithelial cell line NP69 and NPC cell lines (CNE1, CNE2, HNE1 and HONE1), paired cancer tissues and corresponding adjacent normal tissues |
| Expression Pattern | up-regulated |
| Function Description | the expression of ZFAS1 was up-regulated and miR-135a was downregulated in NPC tissues and cells. miR-135a was bound to ZFAS1 in NPC cells. Moreover, knockdown of ZFAS1 or overexpression of miR-135a inhibited cell proliferation, migration and invasion but promoted apoptosis in NPC cells. Besides, deficiency of miR-135a reversed silence of ZFAS1-mediated inhibition of NPC progression in vitro. |
| Pubmed ID | 31307201 |
| Year | 2019 |
| Title | Knockdown of lncRNA ZFAS1 inhibits progression of nasopharyngeal carcinoma by sponging miR-135a |
External Links
| Links for ZFAS1 | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |