Basic Information
| LncRNA/CircRNA Name | ZFAS1 |
| Synonyms | NA |
| Region | GRCh38_20:49278178-49295738 |
| Ensemble | ENSG00000177410 |
| Refseq | NR_003604 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Luciferase reporter assay |
| Sample | NSCLC cell lines (A549, SPCA1, and H1299), the normal human bronchial epithelial cell (16HBE) |
| Expression Pattern | up-regulated |
| Function Description | ZFAS1 expression was significantly higher in NSCLC samples relative to adjacent tissues. The proliferation of NSCLC cells was inhibited by silence of ZFAS1, and conversely, ZFAS2 overexpression promoted the proliferative ability. Further experiments showed that miR-193a-3p was directly targeted by ZFAS1. |
| Pubmed ID | 31378891 |
| Year | 2019 |
| Title | Long noncoding RNA ZFAS1 acts as an oncogene by targeting miR-193a-3p in human non small cell lung cancer |
External Links
| Links for ZFAS1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |