Basic Information
| LncRNA/CircRNA Name | ZFAS1 |
| Synonyms | NA |
| Region | GRCh38_20:49278178-49295738 |
| Ensemble | ENSG00000177410 |
| Refseq | NR_003604 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Western blotting, in vitro knockdown etc. |
| Sample | Thirty cases of gastric cancer tissues with paired adjacent normal tissue samples, Human gastric cancer cells SGC7901 and BGC823 |
| Expression Pattern | up-regulated |
| Function Description | ZFAS1 expression was upregulated, and microRNA-200b-3p (miR-200b) expression was downregulated in gastric cancer tissues. MiR-200b overexpression suppressed the proliferation, cell cycle process, and Wnt/?-catenin signaling of gastric cancer cells. Subsequently, we identified miR-200b is a target of ZFAS1 and Wnt1 is a target of miR-200b. Furthermore, promotion of cancer malignant progression and activation of Wnt/?-catenin signaling induced by ZFAS1 was counteracted by increasing miR-200b expression. In vivo, ZFAS1 knockdown suppressed the tumorigenesis with the upregulated miR-200b and the inactive Wnt/?-catenin signaling. |
| Pubmed ID | 30999814 |
| Year | 2019 |
| Title | Long Non-Coding RNA ZFAS1 Regulates the Malignant Progression of Gastric Cancer via the microRNA-200b-3p/Wnt1 Axis |
External Links
| Links for ZFAS1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |