Basic Information
| LncRNA/CircRNA Name | ZFAS1 |
| Synonyms | NA |
| Region | GRCh38_20:49278178-49295738 |
| Ensemble | ENSG00000177410 |
| Refseq | NR_003604 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , RIP , in vitro knockdown etc. |
| Sample | PTC tissues and noncancerous tissues ,human PTC cell lines(IHH-4 and TPC-1 ,K-1, BCPAP )and human thyroid follicular epithelial cell line Nthy-ori 3-1 |
| Expression Pattern | up-regulated |
| Function Description | We found that the expression of ZFAS1 was increased in PTC tissues and four PTC cell lines.Overexpressing ZFAS1 promoted cell proliferation and inhibited cell apoptosis in PTC cells in vitro.Knockdown of ZFAS1 inhibits tumor growth and upregulation of ZFAS1 promotes tumor growth in vivo. miR-590-3p targeted the 3'-UTR of ZFAS1. miR-590-3p is a target of ZFAS1. miR-590-3p could reverse the effect of ZFAS1 on PTC cells. Moreover, we identified high mobility group AT-hook 2 (HMGA2) to be a downstream target of miR-590-3p and ZFAS1 which activates HMGA2 expression by sponging to miR-590-3p. |
| Pubmed ID | 31571903 |
| Year | 2019 |
| Title | Long Noncoding RNA ZFAS1 Promotes Progression of Papillary Thyroid Carcinoma by Sponging miR-590-3p and Upregulating HMGA2 Expression |
External Links
| Links for ZFAS1 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |