Basic Information
| LncRNA/CircRNA Name | ZFAS1 |
| Synonyms | NA |
| Region | GRCh38_20:49278178-49295738 |
| Ensemble | ENSG00000177410 |
| Refseq | NR_003604 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | head and neck squamous cell carcinoma |
| ICD-0-3 | C76.0 |
| Methods | RT-PCR etc. |
| Sample | HNSCC cell lines(DOK, SCC-040, SCC-25 ,and FaDu ,DOK, SCC-040, and SCC-25 cell lines ,FaDu cell line |
| Expression Pattern | up-regulated |
| Function Description | The expression of ZFAS1 was up-regulated in the metastatic FaDu cell line relative to the less aggressive SCC-25 and SCC-040 and dysplastic DOK cell lines.Patients with a lower expression of ZFAS1 presented a slightly longer disease-free survival and overall survival.In the group of patients with low expression of ZFAS1, we detected the up-regulation of suppressors and down-regulation of genes associated with epithelial-to-mesenchymal transition (EMT) process, metastases, and cancer-initiating cells.oreover, the negative correlation between ZFAS1 and its host gene, ZNFX1, was observed.ZFAS1 has a binding sequence for miR-150-5p.The expression of ZFAS1 and miR-150-5p is negatively correlated in HNSCC patients. miR-150-5p can regulate the 3'UTR of EIF4E mRNA. |
| Pubmed ID | 31010087 |
| Year | 2019 |
| Title | Oncogenic Role of ZFAS1 lncRNA in Head and Neck Squamous Cell Carcinomas |
External Links
| Links for ZFAS1 | GenBank HGNC NONCODE |
| Links for head and neck squamous cell carcinoma | OMIM COSMIC |