Basic Information
| LncRNA/CircRNA Name | ZFAS1 |
| Synonyms | NA |
| Region | GRCh38_20:49278178-49295738 |
| Ensemble | ENSG00000177410 |
| Refseq | NR_003604 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qPCR, Western blot, in vitro knockdown |
| Sample | nasopharyngeal cancer tissues, cell lines (CNE-1 and NP-69) |
| Expression Pattern | up-regulated |
| Function Description | ZFAS1 was overexpressed in NPC patients, which was closely correlated with tumor size and lymph node metastasis of NPC. Moreover, ZFAS1 was negatively correlated to the survival of NPC patients. After interfering with the expression of ZFAS1, the proliferation of NPC cells was significantly decreased, the cell cycle was inhibited and the apoptosis rate was increased. Western Blot showed that ZFAS1 promoted the occurrence of NPC by activating the Wnt/?-catenin pathway. |
| Pubmed ID | 29917194 |
| Year | 2018 |
| Title | Long Non-Coding RNA ZFAS1 Promotes Nasopharyngeal Carcinoma Through Activation of Wnt/?-catenin Pathway |
External Links
| Links for ZFAS1 | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |