Basic Information
| LncRNA/CircRNA Name | ZEB2NAT |
| Synonyms | ZEB2-AS1, ZEB2-AS, ZEB2AS, ZEB2NAT |
| Region | GRCh38_2:144518097-144521477 |
| Ensemble | ENSG00000238057 |
| Refseq | NR_040248 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR etc. |
| Sample | bladder cancer, cell lines (T24, 5637 and J82) |
| Expression Pattern | up-regulated |
| Function Description | A long non-coding RNA, ZEB2NAT, was demonstrated to be essential for this TGFB1-dependent process. ZEB2NAT depletion reversed CAF-CM-induced EMT and invasion of cancer cells, as well as reduced the ZEB2 protein level. Consistently, TGFB1 mRNA expression is positively correlated with ZEB2NAT transcript and ZEB2 protein levels in human bladder cancer specimens. |
| Pubmed ID | 26152796 |
| Year | 2015 |
| Title | TGFB1 secreted by cancer-associated fibroblasts induces epithelial-mesenchymal transition of bladder cancer cells through lncRNA-ZEB2NAT |
External Links
| Links for ZEB2NAT | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |