Basic Information
| LncRNA/CircRNA Name | ZEB2-AS1 |
| Synonyms | NA |
| Region | GRCh38_2:144518097-144521477 |
| Ensemble | ENSG00000238057 |
| Refseq | NR_040248 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | gastric cancer and corresponding cancer-adjacent tissues ,human gastric cancer cell lines (AGS, MKN45,MGC803 and BGC823) and human gastric normal epithelial GES-1 cells |
| Expression Pattern | up-regulated |
| Function Description | The expression of ZEB2-AS1 in cancer tissues was increased compared with cancer-adjacent tissues.Kknockdown of ZEB2-AS1 obviously promoted the apoptosis of AGS cells.Knockdown of ZEB2-AS1 could significantly inhibit the proliferation of AGS cells.Knocking down ZEB2-AS1 could remarkably inhibit the invasion and metastasis of AGS cells.Knocking down ZEB2-AS1 could inhibit cell invasion and metastasis by suppressing the epithelial to mesenchymal transition (EMT) as well as the expressions of matrix metallopeptidase-2 (MMP-2) and MMP-9 in AGS cells. |
| Pubmed ID | 31128021 |
| Year | 2019 |
| Title | Long Non-Coding RNA ZEB2-AS1 Expression Is Associated With Disease Progression and Predicts Outcome in Gastric Cancer Patients |
External Links
| Links for ZEB2-AS1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |