Basic Information
| LncRNA/CircRNA Name | ZEB2-AS1 |
| Synonyms | NA |
| Region | GRCh38_2:144518097-144521477 |
| Ensemble | ENSG00000238057 |
| Refseq | NR_040248 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | head and neck squamous cell carcinoma |
| ICD-0-3 | C76.0 |
| Methods | qPCR, Western blot |
| Sample | HNSCC tissues,cell lines(.HOK, FaDu, Cal27, SCC4 ,SCC25) |
| Expression Pattern | up-regulated |
| Function Description | our findings reveal that overexpression of ZEB2-AS1 associates with tumour aggressiveness and unfavourable prognosis by serving as a putative oncogenic lncRNA and a novel prognostic biomarker in HNSCC. |
| Pubmed ID | 30950191 |
| Year | 2019 |
| Title | Overexpression of ZEB2-AS1 promotes epithelial-to-mesenchymal transition and metastasis by stabilizing ZEB2 mRNA in head neck squamous cell carcinoma. |
External Links
| Links for ZEB2-AS1 | GenBank HGNC NONCODE |
| Links for head and neck squamous cell carcinoma | OMIM COSMIC |