Basic Information
| LncRNA/CircRNA Name | ZEB1-AS1 |
| Synonyms | NR_024284 |
| Region | GRCh38_10:31206278-31320447 |
| Ensemble | ENSG00000237036 |
| Refseq | NR_024284 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | Flow cytometry assay, qPCR, Western blot, etc. |
| Sample | Six CRC cell lines (RKO, Caco2, DLD1, HCT116, LOVO, SW480), HEK293T cells (a human non-CRC cell line) |
| Expression Pattern | up-regulated |
| Function Description | In summary, our findings provide the evidence supporting the role of ZEB1-AS1 as an oncogene in CRC. Our study also demonstrates that miR-181a-5p targets not only protein-coding genes but also the lncRNA ZEB1-AS1. |
| Pubmed ID | 29886791 |
| Year | 2018 |
| Title | The lncRNA ZEB1-AS1 sponges miR-181a-5p to promote colorectal cancer cell proliferation by regulating Wnt/?-catenin signaling. |
External Links
| Links for ZEB1-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |