Basic Information
| LncRNA/CircRNA Name | ZEB1-AS1 |
| Synonyms | NR_024284 |
| Region | GRCh38_10:31206278-31320447 |
| Ensemble | ENSG00000237036 |
| Refseq | NR_024284 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, Western blot, RIP, ChIP, Cell proliferation assay etc. |
| Sample | osteosarcoma tissues, cell lines (hFOB 1.19, HOS, U-2 OS, MG-63, and Saos-2) |
| Expression Pattern | up-regulated |
| Function Description | The results showed that ZEB1-AS1 was upregulated in osteosarcoma tissues and cells. Increased expression of ZEB1-AS1 is correlated with larger tumor size, progressed Enneking stage, tumor metastasis, worse recurrence-free and overall survival of osteosarcoma patients. Functional experiments showed that enhanced expression of ZEB1-AS1 promotes osteosarcoma cells proliferation and migration. By contrast, ZEB1-AS1 knockdown inhibits osteosarcoma cells proliferation and migration. Mechanistically, ZEB1-AS1 directly binds and recruits p300 to the ZEB1 promoter region, induces an open chromatin structure, and activates ZEB1 transcription. |
| Pubmed ID | 27829995 |
| Year | 2016 |
| Title | Long noncoding RNA ZEB1-AS1 acts as an oncogene in osteosarcoma by epigenetically activating ZEB1. |
External Links
| Links for ZEB1-AS1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |