Basic Information
| LncRNA/CircRNA Name | ZEB1-AS1 |
| Synonyms | NR_024284 |
| Region | GRCh38_10:31206278-31320447 |
| Ensemble | ENSG00000237036 |
| Refseq | NR_024284 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | B cell acute lymphoblastic leukemia |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, RIP |
| Sample | B-lineage acute lymphoblastic leukemia blood, cells (BMSC, HS-5, BALL-1) |
| Expression Pattern | up-regulated |
| Function Description | ZEB1-AS1 levels were aberrantly up-regulated in B-ALL. All correlated with STAT3 activation and IL-11 production.a high level of ZEB1-AS1 predicted poor prognosis of B-ALL patients. a high level of ZEB1-AS1 predicted poor prognosis of B-ALL patients. Mechanistically, ZEB1-AS1 could bind to IL-11 and promote IL-11 stability. Down-regulation of ZEB1-AS1 decreased IL-11 production of human bone marrow stromal cells (BMSCs), which led to suppressed proliferation and inhibited IL-11/STAT3 pathway in BALL-1 cells. ZEB1-AS1 promotes the activation of IL-11/STAT3 signaling pathway by associating with IL-11 in B-ALL. |
| Pubmed ID | 28861713 |
| Year | 2017 |
| Title | LncRNA ZEB1-AS1 contributes to STAT3 activation by associating with IL-11 in B-lymphoblastic leukemia. |
External Links
| Links for ZEB1-AS1 | GenBank HGNC NONCODE |
| Links for B cell acute lymphoblastic leukemia | OMIM COSMIC |