Basic Information
| LncRNA/CircRNA Name | ZEB1-AS1 |
| Synonyms | NA |
| Region | GRCh38_10:31206278-31320447 |
| Ensemble | ENSG00000237036 |
| Refseq | NR_024284 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, Western blot etc |
| Sample | PCa tissues,cell lines (RWPE-1,DU145 and LNCaP) |
| Expression Pattern | up-regulated |
| Function Description | ZEB1-AS1 and CUL4B were upregulated and miR-342-3p was downregulated in PCa tissues and cells. Both ZEB1-AS1 and CUL4B inhibition constrained proliferation, migration, and invasion of PCa cells. Moreover, the elevation of CUL4B reversed the effects of ZEB1-AS1 silencing on the proliferation, migration, and invasion of PCa cells. Importantly, ZEB1-AS1 modulated CUL4B expression by sponging miR-342-3p in PCa cells. Besides, ZEB1-AS1 mediated PI3K/AKT/mTOR signal pathway by miR-342-3p/CUL4B axis in PCa cells. |
| Pubmed ID | 32275162 |
| Year | 2020 |
| Title | Downregulation of lncRNA ZEB1-AS1 Represses Cell Proliferation, Migration, and Invasion Through Mediating PI3K/AKT/mTOR Signaling by miR-342-3p/CUL4B Axis in Prostate Cancer |
External Links
| Links for ZEB1-AS1 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |