Basic Information
| LncRNA/CircRNA Name | ZEB1-AS1 |
| Synonyms | NA |
| Region | GRCh38_10:31206278-31320447 |
| Ensemble | ENSG00000237036 |
| Refseq | NR_024284 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | glioma tissues, cell lines (A172, U87, T98G and SHG44) |
| Expression Pattern | up-regulated |
| Function Description | Compared with normal brain tissues and cells, ZEB1-AS1 in glioma tissues and cell lines was shown to be expressed at high levels. Clinical association analysis indicated that ZEB1-AS1 expression was closely associated with tumor size (p = 0.014), KPS (p = 0.004) and WHO grade (p = 0.001). In addition, it was observed that high expression level of ZEB1-AS1 was remarkably associated with overall survival and could be an independent prognostic indicator of glioma using univariate and multivariate analysis. Functional experiments demonstrated that down-regulation of ZEB1-AS1 suppressed the proliferation, invasion, and migration of glioma cell in vitro. In the mechanism, we found that ZEB1-AS1 acted as a competing endogenous RNA to sponge miR-577. Moreover, miR-577 could reverse the tumor-promotive role of ZEB1-AS1 on glioma cells. |
| Pubmed ID | 29863254 |
| Year | 2018 |
| Title | Long Non-Coding RNA ZEB1-AS1 Promotes Glioma Cell Proliferation, Migration and Invasion Through Regulating miR-577 |
External Links
| Links for ZEB1-AS1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |