Basic Information
| LncRNA/CircRNA Name | Z38 |
| Synonyms | CLDND1, Z38, C3orf4, GENX-3745 |
| Region | GRCh38_3:98497912-98523066 |
| Ensemble | ENSG00000080822 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qPCR, Western blot etc. |
| Sample | RCC tissues, cell lines (786-O, A498, ACHIN, SN12PM6) |
| Expression Pattern | up-regulated |
| Function Description | The expression of Z38 was notably increased in patients with stage III and IVRCC compared with patients with stage I and II. Knockdown of Z38 with specifc short hairpin RNAs notably decreased the proliferation rate of A498 and ACHIN cells. In addition, a colony formation assay was included to investigate the role of Z38 in cell proliferation. Transwell assays demonstrated that Z38 deprivation inhibited the migratory and invasive capability of RCC cells. The association between Z38 and the epithelial-mesenchymal transition process was investigated using western blot analysis. |
| Pubmed ID | 28849012 |
| Year | 2017 |
| Title | Long non-coding RNA Z38 promotes cell proliferation and metastasis in human renal cell carcinoma |
External Links
| Links for Z38 | GenBank HGNC NONCODE |
| Links for renal cell carcinoma | OMIM COSMIC |