Basic Information
| LncRNA/CircRNA Name | YIYA |
| Synonyms | LINC00538, PROX1UT, Yiya |
| Region | GRCh38_1:213924749-213926654 |
| Ensemble | ENSG00000281664 |
| Refseq | NR_046189 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, etc. |
| Sample | breast cancer tissues (Yixin-Bre-01, Duke-Bre-01), breast or lung cancer cell lines |
| Expression Pattern | up-regulated |
| Function Description | Our results define a functional role for lncRNA in metabolic reprogramming in cancer, with potential clinical implications for its therapeutic targeting. In clinical specimens of breast cancer, YIYA was expressed in ~40% of cases where it correlated with CDK6 expression and unfavorable survival outcomes. |
| Pubmed ID | 29967256 |
| Year | 2018 |
| Title | Expression of long non-coding RNA YIYA promotes glycolysis in breast cancer. |
External Links
| Links for YIYA | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |