Basic Information
| LncRNA/CircRNA Name | XLOC_010588 |
| Synonyms | TUSC8, LINC01071, XLOC_010588 |
| Region | GRCh38_13:44400250-44405984 |
| Ensemble | ENSG00000237361 |
| Refseq | NR_104174 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, RNAi, Western blot etc. |
| Sample | cervical cancer tissues, cell lines (HeLa, SiHa, HCC94) |
| Expression Pattern | down-regulated |
| Function Description | The results showed that XLOC_010588 expression in cervical cancer was significantly downregulated. Decreased XLOC_010588 expression was correlated with FIGO stage, tumor size and SCC-Ag. Moreover, cervical cancer patients with XLOC_010588 lower expression have shown poorer prognosis. Western blot assays confirmed that XLOC_010588 physically associates with c-Myc, consequently decreasing the expression of c-Myc. The expression of XLOC_010588 and c-Myc is strongly correlated in cervical cancer tissues. |
| Pubmed ID | 24667250 |
| Year | 2014 |
| Title | Low expression of long noncoding XLOC_010588 indicates a poor prognosis and promotes proliferation through upregulation of c-Myc in cervical cancer. |
External Links
| Links for XLOC_010588 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |