Basic Information
| LncRNA/CircRNA Name | XLOC_010588 |
| Synonyms | TUSC8, LINC01071, XLOC_010588 |
| Region | GRCh38_13:44400250-44405984 |
| Ensemble | ENSG00000237361 |
| Refseq | NR_104174 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, in vitro knockdown etc. |
| Sample | cell lines (Caco-2, HT-29, SW480, SW620 and HCT116), CRC tissues |
| Expression Pattern | up-regulated |
| Function Description | Expression of XLOC_010588 was significantly higher in CRC tissues when compared with that in adjacent normal tissues, and that XLOC_010588 was closely associated with metastasis and poor prognosis, thus indicating that XLOC_010588 may function as an oncogene. Additionally, downregulation of XLOC_010588 expression markedly inhibited the invasion and migration of CRC cells. Furthermore, it was demonstrated that XLOC_010588 may regulate the progression of CRC via the epithelial-mesenchymal transition (EMT) pathway. Notably, downregulation of XLOC_010588 inhibited the invasion and migration of CRC cells by regulating genes associated with EMT. |
| Pubmed ID | 29436686 |
| Year | 2018 |
| Title | Downregulation of the long non-coding RNA XLOC_010588 inhibits the invasion and migration of colorectal cancer. |
External Links
| Links for XLOC_010588 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |