Basic Information
| LncRNA/CircRNA Name | XLOC_008466 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, RIP, Luciferase reporter assay etc. |
| Sample | non-small cell lung cancer tissues, cell lines (A549, H460) |
| Expression Pattern | up-regulated |
| Function Description | Up-regulation of XLOC_008466 in NSCLC patients was related to lymph node metastasis and the TNM stage.Experiments on mechanisms revealed that XLOC_008466 functioned as a ceRNA, directly binding to miR-874, and could affect cell proliferation, apoptosis and invasion through regulation of miR-874 expression as well as by increasing matrix metalloproteinase 2 (MMP2) and X-linked inhibitor of apoptosis (XIAP) expression |
| Pubmed ID | 28501870 |
| Year | 2017 |
| Title | Long Non-Coding RNA XLOC_008466 Functions as an Oncogene in Human Non-Small Cell Lung Cancer by Targeting miR-874 |
External Links
| Links for XLOC_008466 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |