Basic Information
| LncRNA/CircRNA Name | XIST |
| Synonyms | XIST, DXS1089, DXS399E, LINC00001, NCRNA00001, SXI1, swd66 |
| Region | GRCh38_X:73820651-73852753 |
| Ensemble | ENSG00000229807 |
| Refseq | NR_001564 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot etc. |
| Sample | colorectal cancer tissues, cell lines (LOVO, HCT116, SW620, SW480 and HT29) |
| Expression Pattern | up-regulated |
| Function Description | The expression level of XIST was significantly increased in both CRC tissues sample and CRC cells.XIST promoted CRC cell proliferation by affecting the cell cycle. In addition, XIST and miR-132-3p were inhibited by each other reciprocally. |
| Pubmed ID | 28730777 |
| Year | 2017 |
| Title | Long non-coding RNA XIST functions as an oncogene in human colorectal cancer by targeting miR-132-3p |
External Links
| Links for XIST | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |