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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis		Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	pancreatic cancer
ICD-0-3	C25
Methods	qPCR, Luciferase reporter assay, Cell proliferation assay, MTT assay etc.
Sample	prostate cancer tissues, cell lines (Patu8988, SW1990, BxPC-3, AsPC-1, CFPAC-1 and Panc-1)
Expression Pattern	up-regulated
Function Description	lncRNA-XIST was specifically upregulated in PC tissues and cell lines, and high XIST expression in PC was related to poorer prognosis (larger tumor size, perineural invasion, lymph node micrometastases and shorter overall survival). XIST augmented PC cell proliferation. In the present study, XIST and miR-133a reciprocally inhibited each other in PC cells. Exogenous miR-133a expression significantly inhibited PC cell proliferation. Moreover, as exhibited by luciferase reporter gene assays, miR-133a bound to XIST and the 3'UTR of EGFR by direct targeting. In PC tissues, miR-133a expression was down-regulated and EGFR expression was up-regulated; miR-133a was inversely correlated with EGFR and XIST, respectively; XIST was positively correlated with EGFR. Taken together, these findings will shed light on the role and mechanism of XIST/miR-133a/EGFR in regulating PC cells proliferation.
Pubmed ID	28295543
Year	2017
Title	LncRNA XIST Promotes Pancreatic Cancer Proliferation through miR-133a/EGFR.

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