Basic Information
| LncRNA/CircRNA Name | XIST |
| Synonyms | XIST, DXS1089, DXS399E, LINC00001, NCRNA00001, SXI1, swd66 |
| Region | GRCh38_X:73820651-73852753 |
| Ensemble | ENSG00000229807 |
| Refseq | NR_001564 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qPCR, Western blot etc. |
| Sample | nasopharyngeal carcinoma tissues, cell lines (CNE1, CNE2, SUNE-1 and C666-1) |
| Expression Pattern | up-regulated |
| Function Description | XIST expression was significantly upregulated in NPC tissues and cell lines. Knockdown of XIST inhibited NPC cell proliferation and invasion and induced apoptosis in vitro,as well as suppressed NPC tumor growth in vivo. Further analysis revealed that XIST and miR-491-5p interact with and repress each other.XIST may function as an endogenous miR-491-5p sponge to regulate the target gene of miR-491-5p. |
| Pubmed ID | 29219216 |
| Year | 2018 |
| Title | Knockdown of long non-coding RNA XIST suppresses nasopharyngeal carcinoma progression by activating miR-491-5p. |
External Links
| Links for XIST | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |