Basic Information
| LncRNA/CircRNA Name | XIST |
| Synonyms | XIST, DXS1089, DXS399E, LINC00001, NCRNA00001, SXI1, swd66 |
| Region | GRCh38_X:73820651-73852753 |
| Ensemble | ENSG00000229807 |
| Refseq | NR_001564 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | cell lines (AsPC-1, BxPC3, SW1990,PANC-1, CAPAN-1, CAPAN-2) |
| Expression Pattern | up-regulated |
| Function Description | XIST might be an oncogenic lncRNA that promoted proliferation of PC cell line through inhibiting miR- 140/miR-124 expression and promoting cell cycle-related factor expression, and could be regarded as a therapeutic target in human pancreatic carcinoma.XIST is highly expressed in PC tissues and cell line and related with clinicopathologic features. |
| Pubmed ID | 29371940 |
| Year | 2017 |
| Title | The lncRNA XIST interacts with miR-140/miR-124/iASPP axisto promote pancreatic carcinoma growth |
External Links
| Links for XIST | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |