Basic Information
| LncRNA/CircRNA Name | XIST |
| Synonyms | XIST, DXS1089, DXS399E, LINC00001, NCRNA00001, SXI1, swd66 |
| Region | GRCh38_X:73820651-73852753 |
| Ensemble | ENSG00000229807 |
| Refseq | NR_001564 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | testicular germ cell tumor |
| ICD-0-3 | C62 |
| Methods | qPCR etc. |
| Sample | testicular germ cell tumor tissues, cell lines (Team-2, JKT-1, ITO-II etc.) |
| Expression Pattern | up-regulated |
| Function Description | XIST expression was common in seminomatous testicular germ cell tumors (2 of 2 or 100% of seminoma derived cell lines and 10 of 12 or 83% of seminomatous testicular germ cell tumor tissues) but not in nonseminomatous testicular germ cell tumors (0 of 2 or 0% nonseminoma derived cell lines and 2 of 8 or 25% of nonseminomatous testicular germ cell tumor tissues). The current data may suggest the potential oncogenic implications of X chromosomal gain in testicular germ cell tumors. |
| Pubmed ID | 12629412 |
| Year | 2003 |
| Title | The roles of supernumerical X chromosomes and XIST expression in testicular germ cell tumors. |
External Links
| Links for XIST | GenBank HGNC NONCODE |
| Links for testicular germ cell tumor | OMIM COSMIC |