Basic Information
| LncRNA/CircRNA Name | XIST |
| Synonyms | XIST, DXS1089, DXS399E, LINC00001, NCRNA00001, SXI1, swd66 |
| Region | GRCh38_X:73820651-73852753 |
| Ensemble | ENSG00000229807 |
| Refseq | NR_001564 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cancer |
| ICD-0-3 | C15 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | esophageal squamous tissues, cell lines (KYSE30, KYSE510, KYSE410, KYSE520, KYSE140 and KYSE150) |
| Expression Pattern | up-regulated |
| Function Description | XIST was significantly upregulated in esophageal squamous cancerous tissues and cancer cell lines,as compared with that in the corresponding non-cancerous tissues and immortalized normal squamous epithelial cells. High XIST expression predicted poor prognosis of esophageal squamous cancer patients. Lentivirus mediated knockdown of XIST inhibited proliferation, migration and invasion of esophageal squamous cancer cells in vitro and suppressed tumor growth in vivo. Knockdown of XIST resulted in elevated expression of miR-101 and decreased expression of EZH2. Further analysis showed that XIST functioned as the competitive endogenous RNA of miR-101 to regulate EZH2 expression. Our results showed that patients with high XIST level had a significantly shortened overall survival as well as disease-free survival than those with low XIST level. |
| Pubmed ID | 29100288 |
| Year | 2017 |
| Title | Long noncoding RNA XIST promotes malignancies of esophageal squamous cell carcinoma via regulation of miR-101/EZH2. |
External Links
| Links for XIST | GenBank HGNC NONCODE |
| Links for esophageal squamous cancer | OMIM COSMIC |