Basic Information
| LncRNA/CircRNA Name | XIST |
| Synonyms | XIST, DXS1089, DXS399E, LINC00001, NCRNA00001, SXI1, swd66 |
| Region | GRCh38_X:73820651-73852753 |
| Ensemble | ENSG00000229807 |
| Refseq | NR_001564 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | fibrosarcoma |
| ICD-0-3 | NA |
| Methods | RNA-FISH, BrUTP transcription assay, DNA-FISH etc. |
| Sample | cell lines (HT-1080 clones) |
| Expression Pattern | differential expression |
| Function Description | Here we investigate four adult male HT-1080 fibrosarcoma cell lines expressing ectopic human XIST and demonstrate that these post differentiation cells can undergo chromosomal inactivation outside of any normal developmental context. All four clonal lines inactivated the transgene-containing autosome to varying degrees and with variable stability. One clone in particular consistently localized the ectopic XIST RNA to a discrete chromosome territory that exhibited striking hallmarks of inactivation, including long-range transcriptional inactivation. |
| Pubmed ID | 12072569 |
| Year | 2002 |
| Title | An ectopic human XIST gene can induce chromosome inactivation in postdifferentiation human HT-1080 cells. |
External Links
| Links for XIST | GenBank HGNC NONCODE |
| Links for fibrosarcoma | OMIM COSMIC |