Basic Information
| LncRNA/CircRNA Name | XIST |
| Synonyms | XIST, DXS1089, DXS399E, LINC00001, NCRNA00001, SXI1, swd66 |
| Region | GRCh38_X:73820651-73852753 |
| Ensemble | ENSG00000229807 |
| Refseq | NR_001564 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | renal collecting duct carcinoma |
| ICD-0-3 | C64.9 |
| Methods | Microarray, Western blot etc. |
| Sample | cell lines (AP3, AP8-CDC etc.) |
| Expression Pattern | up-regulated |
| Function Description | In cell lines created from the tissue of both a male patient and a female patient with collecting duct carcinoma of the kidney, the XIST gene, along with several other chromosome X genes, was found to have an increase in copy number. The results suggest that TOP1 might be one of the molecular targets in AP8 CDC cells. Thus, these novel CDC cell lines will be useful for discovering therapeutic targets and developing effective anticancer drugs against CDC. |
| Pubmed ID | 19154479 |
| Year | 2009 |
| Title | Genetic alterations and chemosensitivity profile in newly established human renal collecting duct carcinoma cell lines. |
External Links
| Links for XIST | GenBank HGNC NONCODE |
| Links for renal collecting duct carcinoma | OMIM COSMIC |