Basic Information
| LncRNA/CircRNA Name | XIST |
| Synonyms | NA |
| Region | GRCh38_X:73820651-73852753 |
| Ensemble | ENSG00000229807 |
| Refseq | NR_001564 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | neuroblastoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, in vitro knockdown, RIP |
| Sample | Neuroblastoma cells including the cell line without MYCN amplification (SH-SY5Y) and MYCN-amplified cell line SK-N-BE (2), The Human Embryonic Kidney 293 (HEK293) cells, neuroblastoma tissues, the normal adrenal tissues |
| Expression Pattern | up-regulated |
| Function Description | XIST was significantly up-regulated in neuroblastoma tissues (n=30) and cells lines, and it was statistically associated with the age and International Neuroblastoma Staging System (INSS) staging in neuroblastoma patients. Down-regulation of XIST suppressed the growth, migration and invasion of neuroblastoma cells. EZH2 inhibited DKK1 expression through inducing H3 histone methylation in its promoter. XIST increased the level of H3K27me3 in DKK1 promoter via interacting with EZH2. Down-regulation of XIST increased DKK1 expression to suppress neuroblastoma cell growth, invasion, and migration, which markedly restrained the tumor progression. |
| Pubmed ID | 31208278 |
| Year | 2019 |
| Title | LncRNA XIST facilitates cell growth, migration and invasion via modulating H3 histone methylation of DKK1 in neuroblastoma |
External Links
| Links for XIST | GenBank HGNC NONCODE |
| Links for neuroblastoma | OMIM COSMIC |