Basic Information
| LncRNA/CircRNA Name | XIST |
| Synonyms | NA |
| Region | GRCh38_X:73820651-73852753 |
| Ensemble | ENSG00000229807 |
| Refseq | NR_001564 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR, Western blot, Luciferase reporter assay |
| Sample | Pancreatic cancer cell line PANC-1 and human embryonic kidney cell HEK293T, tumor tissues and adjacent normal tissues |
| Expression Pattern | up-regulated |
| Function Description | 1)XIST is highly expressed in tumor tissues while miR-141-3p is down-regulated. 2)Silencing XIST inhibits the pancreatic cell proliferation, migration and invasion. 3)MiR-141-3p inhibitor alleviates the inhibitory effect by siXIST in pancreatic cancer cell lines. 4)MiR-141-3p directly interacts with XIST and also negatively regulates TGF-?2 expression. 5)Overexpression of XIST attenuates the inhibition of TGF-?2 expression by miR-141-3p. |
| Pubmed ID | 31213574 |
| Year | 2019 |
| Title | LncRNA XIST enhanced TGF-?2 expression by targeting miR-141-3p to promote pancreatic cancer cells invasion |
External Links
| Links for XIST | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |