Basic Information
| LncRNA/CircRNA Name | XIST |
| Synonyms | NA |
| Region | GRCh38_X:73820651-73852753 |
| Ensemble | ENSG00000229807 |
| Refseq | NR_001564 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay |
| Sample | Human NSCLC cell lines A549, H1299, H23, H522, H460, H1650 and 95D, NSCLC tumor tissues and non-tumor tissues |
| Expression Pattern | up-regulated |
| Function Description | The expression of LncRNA XIST was significantly up-regulated in NSCLC tissues. In addition, overexpression of XIST was positively correlated with the advanced clinical status of tumors, as well as poor OS and DFS. A tumor suppressive effect was presented via functional knockdown of LncRNA XIST. Up-regulation of XIST enhanced the proliferation, migration and invasion ability of NSCLC cells both in vivo and in vitro. Mechanically, it was indicated that XIST could serve as an endogenous competitive RNA modulating miR-744, leading to the miR-744/RING1 signaling pathway inhibition and Wnt/?-catenin signaling pathway activation. |
| Pubmed ID | 31292221 |
| Year | 2019 |
| Title | Downregulation of LncRNA XIST Inhibits Cell Proliferation via Regulating miR-744/RING1 Axis in non small cell lung cancer |
External Links
| Links for XIST | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |