Basic Information
| LncRNA/CircRNA Name | XIST |
| Synonyms | NA |
| Region | GRCh38_X:73820651-73852753 |
| Ensemble | ENSG00000229807 |
| Refseq | NR_001564 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal cancer |
| ICD-0-3 | C15 |
| Methods | qPCR, Western blot, Luciferase reporter assay, etc. |
| Sample | ESCC cancerous, Normal esophageal epithelial cell line HEEC, adenocarcinoma cell lines (SKGT-4 and Bic-1) and ESCC cell lines (TE-1, HCE-4 and HCE-7) |
| Expression Pattern | up-regulated |
| Function Description | LncRNA XIST was overespressed in esophageal cancer tissues and cells. Suppression of XIST significantly inhibited the proliferation, migration and invasion, but induced apoptosis of two kinds of cells, TE-1 and SKGT-4. Moreover, miR-494 was down-regulated in esophageal cancer tissues and cells. XIST could sponge miR-494 and inhibition of miR-494 reversed the effects of XIST suppression on the malignant behaviors of TE-1 cells. Also, CDK6 was a target of miR-494 and CDK6 knockdown reversed the effects of miR-494 inhibition on the malignant behaviors of TE-1 cells. Besides, the expression of p-JAK2 and p-STAT3 was increased after miR-494 inhibition, which was reversed after inhibition of miR-494 and CDK6 at the same time. |
| Pubmed ID | 30551480 |
| Year | 2019 |
| Title | Long Non-Coding RNA XIST Promotes the Development of Esophageal Cancer by Sponging miR-494 to Regulate CDK6 Expression |
External Links
| Links for XIST | GenBank HGNC NONCODE |
| Links for esophageal cancer | OMIM COSMIC |