Basic Information
| LncRNA/CircRNA Name | XIST |
| Synonyms | NA |
| Region | GRCh38_X:73820651-73852753 |
| Ensemble | ENSG00000229807 |
| Refseq | NR_001564 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, in vitro knockdown, etc. |
| Sample | OS tissues, OS cell lines (KHOS-240S, SaOS2, MG-63, SOSP-9607 and U2OS), and osteoblastic cell line (hFOB1.19) |
| Expression Pattern | up-regulated |
| Function Description | Increased lncRNA XIST expression was observed in osteosarcoma tissues compared with the normal tissues and was positively associated with advanced Enneking stage. In addition, lncRNA XIST may be used as an independent risk factor for the overall survival of patients with osteosarcoma. Knockdown of lncRNA XIST inhibited cell proliferation, induced cell apoptosis and arrested the cell cycle. The inhibition of lncRNA XIST may also suppress cell migration and invasion in vitro. |
| Pubmed ID | 30655762 |
| Year | 2019 |
| Title | Long non-coding RNA XIST predicts poor prognosis and promotes malignant phenotypes in osteosarcoma |
External Links
| Links for XIST | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |