Basic Information
| LncRNA/CircRNA Name | XIST |
| Synonyms | NA |
| Region | GRCh38_X:73820651-73852753 |
| Ensemble | ENSG00000229807 |
| Refseq | NR_001564 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, etc. |
| Sample | CRC tissues, Human colorectal cancer cell lines (i.e. HCT116, HT29, SW620, and SW480) and the normal colorectal cell line (i.e. CCD-116CoN) |
| Expression Pattern | up-regulated |
| Function Description | CRC tissues and cells were detected with significantly elevated XIST and NRP 2 expressions as well as markedly reduced miR 486 5p expression when compared with normal tissues and cells (all p < 0.05). Besides this, the highly expressed XIST and NRP 2, as well as the lowly expressed miR 486 5p all could substantially encourage proliferation and EMT of CRC cells and simultaneously restrict apoptosis of the cells (p < 0.05). Moreover, XIST was found to directly target miR 486 5p, and NRP 2 was directly targeted and modulated by miR 486 5p. Finally, CRC cells of the miR NC + pcDNA3.1 NRP 2 groups showed stronger proliferation, viability, and EMT than those of miR NC and miR 486 5p mimic groups (p < 0.05). |
| Pubmed ID | 30656681 |
| Year | 2019 |
| Title | LncRNA XIST facilitates proliferation and epithelial-mesenchymal transition of colorectal cancer cells through targeting miR-486-5p and promoting neuropilin-2 |
External Links
| Links for XIST | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |