Basic Information
| LncRNA/CircRNA Name | XIST |
| Synonyms | NA |
| Region | GRCh38_X:73820651-73852753 |
| Ensemble | ENSG00000229807 |
| Refseq | NR_001564 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Dual luciferase reporter assay |
| Sample | hepatocellular carcinoma tissues, cell line HepG2 |
| Expression Pattern | down-regulated |
| Function Description | JPX and XIST expression was significantly decreased in HCC pathologic specimens. Dual luciferase reporter assay revealed XIST as a direct target of miR-155-5p. These data suggested that JPX could decrease cell proliferation, while increasing apoptosis, in HepG2 cells possibly through XIST, which inhibits the function of miR-155-5p.XIST knock-in significantly reduced miR-155-5p expression level and increased that of SOX6 and PTEN, while significantly inhibiting HepG2 cell growth in vitro, which was partially reversed by miR-155-5p mimic transfection. |
| Pubmed ID | 30091314 |
| Year | 2018 |
| Title | XIST Induced by JPX Suppresses Hepatocellular Carcinoma by Sponging miR-155-5p. |
External Links
| Links for XIST | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |