Basic Information
| LncRNA/CircRNA Name | XIST |
| Synonyms | NA |
| Region | GRCh38_X:73820651-73852753 |
| Ensemble | ENSG00000229807 |
| Refseq | NR_001564 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qRT-PCR , Luciferase reporter assay , in vitro knockdown etc. |
| Sample | bladder cancer tissues and adjacent tissues?,normal urinary tract epithelial cell line SV-HUC-1 ,common bladder cancer cell lines(T24, 253J, RT112 and HT-1376) |
| Expression Pattern | up-regulated |
| Function Description | XIST was significantly upregulated in bladder cancer tissues compared with that in adjacent normal tissues. Furthermore, its expression was reduced in several common bladder cancer cell lines. High expression of XIST was significantly associated with tumour progression and poor prognosis of patients with bladder cancer.Knockdown of XIST significantly reduced the proliferation and migration of bladder cancer cells.XIST binds to its predicted binding site in miR-133a.In addition, miR-133a was significantly downregulated in bladder cancer, and its expression levels were inversely correlated with those of XIST in bladder cancer tissues.Furthermore,miR-133a acted as a downstream effector in XIST-mediated bladder cancer cell proliferation and migration. |
| Pubmed ID | 31602223 |
| Year | 2019 |
| Title | Long Non-Coding RNA XIST Promotes Cell Proliferation and Migration Through Targeting miR-133a in Bladder Cancer |
External Links
| Links for XIST | GenBank HGNC NONCODE |
| Links for bladder cancer | OMIM COSMIC |