Basic Information
| LncRNA/CircRNA Name | XIST |
| Synonyms | NA |
| Region | GRCh38_X:73820651-73852753 |
| Ensemble | ENSG00000229807 |
| Refseq | NR_001564 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | laryngeal squamous cell cancer |
| ICD-0-3 | C32.3 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | tumor tissues and adjacent non-cancerous matched tissues , Human LSCC cell line Hep-2 and HEK293T cell |
| Expression Pattern | up-regulated |
| Function Description | XIST was highly upregulated in laryngeal squamous cancerous (LSCC) tissues. Knockdown of XIST, mediated by lentiviral transfection of XIST-specific short-hairpin RNA (shRNA), led to the inhibition of proliferation, migration, and invasion of LSCC cells in vitro. In vivo, XIST knockdown also suppressed the growth of LSCC xenografts in mice.Upregulation of miR-124 and downregulation of EZH2 were concomitantly observed after XIST knockdown, XIST served as the competitive endogenous RNA of miR-124 to modulate EZH2 expression.Moreover, ectopic overexpression of EZH2 prominently attenuated the anti-proliferation activity by XIST knockdown. Therefore,XIST plays an important role in progression of LSCC by modulating the miR-124-EZH2 axis. |
| Pubmed ID | 31071316 |
| Year | 2019 |
| Title | Long Noncoding RNA XIST Increases the Aggressiveness of Laryngeal Squamous Cell Carcinoma by Regulating miR-124-3p/EZH2 |
External Links
| Links for XIST | GenBank HGNC NONCODE |
| Links for laryngeal squamous cell cancer | OMIM COSMIC |